Dr. Eng. Paulina Błaszkiewicz
Degree:
Ph.D. in Engineering and Technical Sciences in the discipline of Materials Engineering, Poznań University of Technology
paulina.blaszkiewicz@amu.edu.pl
Research interests:
Synthesis and functionalization of metallic nanoparticles
Nanoparticle-dye hybrid systems
Photodynamic/photothermal therapy
Selected publications:
1. B. Tim, P. Błaszkiewicz, E.Coy. A. Dudkowiak, Interactions between functionalized PEGylated gold nanoparticles and model biological membranes, Journal of Molecular Liquids, 2025, 428, 127501. (IF=5.3; pkt. MEiN=100)
2. D. Ziental, P. Błaszkiewicz, J. Długaszewska, E. Güzel, A. Dudkowiak, Ł. Sobotta, Modified gold nanoparticles modulated fluorescence and singlet oxygen generation of pheophorbide a as an effective platform for photodynamic therapy against Staphylococcus aureus, European Journal of Inorganic Chemistry, 2024 (IF=2.551; pkt. MEiN=70)
3. P. Talarska, P. Błaszkiewicz, A. Kostrzewa, P. Wirstlein, M. Cegłowski, G. Nowaczyk, A. Dudkowiak, B. O. Grabarek, P. Głowacka-Stalmach, A. Szarpak, J. Żurawski, Effects of Spherical and Rod-like Gold Nanoparticles on the Reactivity of Human Peripheral Blood Leukocytes, Antioxidants, 2024, 13, 157 (IF=7.675; pkt. MEiN=100)
4. J. Sikora, P. Błaszkiewicz, A. Dudkowiak, J. Jagielska, J. Żurawski, Cytotoxicity of gold nanoparticles to human lymphocytes: a comparison between rod-shaped and spherical nanoparticles, Contemporary Oncology/Współczesna Onkologia, 2024, 28(4), 326–334. (IF=2.9; pkt. MEiN=70)
Projects:
SONATINA 7: Hybrid Nanocomposites Based on Gold Nanoparticles as Promising Photoactive Materials for Combined Photothermal/Photodynamic Therapy – HyPhoto2
Supervisory institution: National Science Center
Project manager: Dr Eng. Paulina Błaszkiewicz
Budget: 924 228 PLN
Start date: 2023-12-01
Duration: 3 years
Contract number: UMO-2023/48/C/ST4/00067
Abstract:
The development of methods and possibilities for producing nanomaterials implies progress in the field of improvement and application of new medical procedures. Interdisciplinary research is carried out on many levels in order to find effective diagnostic and/or therapeutic methods using e.g. metallic nanoparticles. Determining the photophysical properties of nanoparticles and examining their interactions with biological material provides important information to create increasingly better drug or vaccine delivery systems and to identify the occurrence of potential side effects. The HyPhoto2 project proposes to conduct basic research for systems based on gold nanoparticles, which in the area of the so-called therapeutic window (above 650 nm) show plasmon resonance, associated with the interaction of light with free electrons of metallic nanostructures. The interaction of surface plasmons with the dye may affect the efficiency of photophysical processes, important from the point of view of potential applications of metal-dye hybrid systems in photomedicine. The results of the research will provide important information about the photophysical properties of the tested, functionalized nanoparticles and their hybrid nanocomposites, and will indicate the potential possibility of their use in biomedical applications.
2. D. Ziental, P. Błaszkiewicz, J. Długaszewska, E. Güzel, A. Dudkowiak, Ł. Sobotta, Modified gold nanoparticles modulated fluorescence and singlet oxygen generation of pheophorbide a as an effective platform for photodynamic therapy against Staphylococcus aureus, European Journal of Inorganic Chemistry, 2024 (IF=2.551; pkt. MEiN=70)
3. P. Talarska, P. Błaszkiewicz, A. Kostrzewa, P. Wirstlein, M. Cegłowski, G. Nowaczyk, A. Dudkowiak, B. O. Grabarek, P. Głowacka-Stalmach, A. Szarpak, J. Żurawski, Effects of Spherical and Rod-like Gold Nanoparticles on the Reactivity of Human Peripheral Blood Leukocytes, Antioxidants, 2024, 13, 157 (IF=7.675; pkt. MEiN=100)
4. J. Sikora, P. Błaszkiewicz, A. Dudkowiak, J. Jagielska, J. Żurawski, Cytotoxicity of gold nanoparticles to human lymphocytes: a comparison between rod-shaped and spherical nanoparticles, Contemporary Oncology/Współczesna Onkologia, 2024, 28(4), 326–334. (IF=2.9; pkt. MEiN=70)
Projects:
SONATINA 7: Hybrid Nanocomposites Based on Gold Nanoparticles as Promising Photoactive Materials for Combined Photothermal/Photodynamic Therapy – HyPhoto2
Supervisory institution: National Science Center
Project manager: Dr Eng. Paulina Błaszkiewicz
Budget: 924 228 PLN
Start date: 2023-12-01
Duration: 3 years
Contract number: UMO-2023/48/C/ST4/00067
Abstract:
The development of methods and possibilities for producing nanomaterials implies progress in the field of improvement and application of new medical procedures. Interdisciplinary research is carried out on many levels in order to find effective diagnostic and/or therapeutic methods using e.g. metallic nanoparticles. Determining the photophysical properties of nanoparticles and examining their interactions with biological material provides important information to create increasingly better drug or vaccine delivery systems and to identify the occurrence of potential side effects. The HyPhoto2 project proposes to conduct basic research for systems based on gold nanoparticles, which in the area of the so-called therapeutic window (above 650 nm) show plasmon resonance, associated with the interaction of light with free electrons of metallic nanostructures. The interaction of surface plasmons with the dye may affect the efficiency of photophysical processes, important from the point of view of potential applications of metal-dye hybrid systems in photomedicine. The results of the research will provide important information about the photophysical properties of the tested, functionalized nanoparticles and their hybrid nanocomposites, and will indicate the potential possibility of their use in biomedical applications.
