Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin – piperine nutraceutical system with improved enzyme inhibition properties

Rok publikacji: 2020
Wydawca:  Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 35, 2020 - Issue 1
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A. Stasiłowicz, E. Tykarska, K. Lewandowska, M. Kozak, A. Miklaszewski, J. Kobus-Cisowska, D. Szymanowska, T. Plech, J. Jenczyk, J. Cielecka-Piontek
The nutraceutical system of curcumin-piperine in 2-hydroxypropyl-β-cyclodextrin was prepared by using the kneading technique. Interactions between the components of the system were defined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR). Application of hydroxypropyl-β-cyclodextrin as a carrier-solubiliser improved solubility of the curcumin–piperine system, its permeability through biological membranes (gastrointestinal tract, blood–brain barrier) as well as the antioxidant, antimicrobial and enzyme inhibitory activities against acetylcholinesterase and butyrylcholinesterase.

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