Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin – piperine nutraceutical system with improved enzyme inhibition properties

Publish Year: 2020
Publisher:  Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 35, 2020 - Issue 1
See this publication
A. Stasiłowicz, E. Tykarska, K. Lewandowska, M. Kozak, A. Miklaszewski, J. Kobus-Cisowska, D. Szymanowska, T. Plech, J. Jenczyk, J. Cielecka-Piontek
The nutraceutical system of curcumin-piperine in 2-hydroxypropyl-β-cyclodextrin was prepared by using the kneading technique. Interactions between the components of the system were defined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR). Application of hydroxypropyl-β-cyclodextrin as a carrier-solubiliser improved solubility of the curcumin–piperine system, its permeability through biological membranes (gastrointestinal tract, blood–brain barrier) as well as the antioxidant, antimicrobial and enzyme inhibitory activities against acetylcholinesterase and butyrylcholinesterase.

Contact | Contact database | RSS | Login
© 2022 CENTRUM NANOBIOMEDYCZNE UAM | ul. Wszechnicy Piastowskiej 3, PL 61614 Poznań, Poland | tel.+48 61 829 67 04.